Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation
نویسندگان
چکیده
منابع مشابه
Ginsenoside Rg1 attenuates oligomeric Aβ(1-42)-induced mitochondrial dysfunction.
Mitochondrial dysfunction is one of the major pathological changes seen in Alzheimer's disease (AD). Amyloid beta-peptide (Aβ), a neurotoxic peptide, accumulates in the brain of AD subjects and mediates mitochondrial and neuronal stress. Therefore, protecting mitochondrion from Aβ-induced toxicity holds potential benefits for halting and treating and perhaps preventing AD. Here, we report that ...
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Activated microglia and reactive astrocytes are commonly found in and around the senile plaque, which is the central pathological hallmark of Alzheimer's disease. Astrocytes respond to neuronal activity through the release of gliotransmitters such as glutamate, D-serine, and ATP. However, it is largely unknown whether and how gliotransmitters affect neuronal functions. In this study, we explore...
متن کاملمدل ساز ی به روش شبیه سازی دینامیک مولکولی مونومر Aβ (1-42) و Aβ (1-40) ، به منظور مقایسه نقش آن‌ها در ایجاد بیماری آلزایمر
سابقه و هدف: مطالعه های آسیب‌شناختی، تشکیل پلاک‌های فیبری و توده‌های تجمع یافته پپتید آمیلوئید بتا (Aβ) را یکی از دلایل بیماری آلزایمر پیشنهاد کرده‌اند. از آنجا که این بیماری وابسته به ساختار فضایی پروتئین است در این مقاله به روش شبیه سازی دینامیک مولکولی مراحل آغازین تغییرهای کنفورماسیون دو مونومر از Aβ، Aβ (1-42) و Aβ (1-40) مورد بررسی قرار میگیرد. مواد و روش ها: ساختار NMR دو پپتید Aβ (...
متن کاملAβ(39-42) modulates Aβ oligomerization but not fibril formation.
Recently, certain C-terminal fragments (CTFs) of Aβ42 have been shown to be effective inhibitors of Aβ42 toxicity. Here, we examine the interactions between the shortest CTF in the original series, Aβ(39-42), and full-length Aβ. Mass spectrometry results indicate that Aβ(39-42) binds directly to Aβ monomers and to the n = 2, 4, and 6 oligomers. The Aβ42:Aβ(39-42) complex is further probed using...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19072109